Magnesium Breakthrough | BIOptimizers | 60 Veggie Caps

• May reduce cortisol
• May reduce stress
• May relieve muscle aches
• May speed up muscle recovery
• May promote deep relaxation and better sleep
  
• 1 bottle of 60 capsules (30 servings)
• Gluten-free, Soy-free and Lactose-free
• Free from chemicals & fillers

MAGNESIUM CHELATE

This form of magnesium is especially important for muscle building, & recovery.

MAGNESIUM CITRATE

One study found that this form helped arterial stiffness in healthy overweight individuals.

MAGNESIUM BISGLYCINATE

Often used to treat symptoms of excess stomach acid, such as stomach upset, heartburn, and acid indigestion.

MAGNESIUM MALATE

Some believe this to be the most bioavailable form of magnesium. It’s found naturally in fruits, giving them a “tart taste.” Magnesium Malate can help with migraines, chronic pain, and depression.

MAGNESIUM SUCROSOMIAL

This form of magnesium helps you to effectively produce energy. It also supports the immune system and is critical for bone health and skeletal development.

MAGNESIUM TAURATE

This is the form of magnesium best for your heart. 

MAGNESIUM OROTATE

While also helpful for the heart, magnesium orotate is believed to be the best form for metabolic improvements. This makes it a favourite for athletes seeking enhanced recovery, energy and performance.

Magnesium Breakthrough has been detected free of Mercury, Lead, Arsenic and Fluoride. Each batch is produced under strict quality control standards. Gluten Free. 

Other Ingredients:
Cellulose (capsule), Nu-Mag®, Nu-Flow®, Silica.

Store in a cool/dry location away from direct light.

CAUTION

Keep out of reach of children. As with any product, discontinue immediately if adverse effects occur. Please consult a physician before beginning any new supplement, diet, training program, or if you are undergoing treatment of a medical condition.

Scientific Studies

1. de Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiol Rev. 2015;95(1):1-46. doi:10.1152/physrev.00012.2014
2. DiNicolantonio JJ, Liu J, O'Keefe JH. Magnesium for the prevention and treatment of cardiovascular disease. Open Heart. 2018;5(2):e000775. Published 2018 Jul 1. doi:10.1136/openhrt-2018-000775
3. Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
4. Pouteau E, Kabir-Ahmadi M, Noah L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454. Published 2018 Dec 18. doi:10.1371/journal.pone.0208454
5. Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362-370. doi:10.1016/j.mehy.2006.01.047
6. Tarleton EK, Littenberg B, MacLean CD, Kennedy AG, Daley C. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial. PLoS One. 2017;12(6):e0180067. Published 2017 Jun 27. doi:10.1371/journal.pone.0180067
7. Botturi A, Ciappolino V, Delvecchio G, Boscutti A, Viscardi B, Brambilla P. The Role and the Effect of Magnesium in Mental Disorders: A Systematic Review. Nutrients. 2020;12(6):1661. Published 2020 Jun 3. doi:10.3390/nu12061661
8. Barragán-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F. Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial. Magnes Res. 2008;21(4):218-223.
9. Guerrero-Romero F, Tamez-Perez HE, González-González G, et al. Oral magnesium supplementation improves sensitivity in non-diabetic subjects with resistance. A double-blind placebo-controlled randomized trial. Diabetes Metab. 2004;30(3):253-258. doi:10.1016/s1262-3636(07)70116-7
10. Takaya J, Higashino H, Kobayashi Y. Intracellular magnesium and resistance. Magnes Res. 2004;17(2):126-136.
11. Schnack C, Bauer I, Pregant P, Hopmeier P, Schernthaner G. Hypomagnesaemia in type 2 diabetes mellitus is not corrected by improvement of long-term metabolic control. Diabetologia. 1992;35(1):77-79. doi:10.1007/BF00400855
12. Rodríguez-Morán M, Guerrero-Romero F. Oral magnesium supplementation improves sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care. 2003;26(4):1147-1152. doi:10.2337/diacare.26.4.1147
13. Askari M, Mozaffari H, Jafari A, Ghanbari M, Darooghegi Mofrad M. The effects of magnesium supplementation on obesity measures in adults: a systematic review and dose-response meta-analysis of randomized controlled trials [published online ahead of print, 2020 Jul 11]. Crit Rev Food Sci Nutr. 2020;1-17. doi:10.1080/10408398.2020.1790498
14. Asemi Z, Karamali M, Jamilian M, et al. Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(1):222-229. doi:10.3945/ajcn.114.098616
15. Zhang Y, Xun P, Wang R, Mao L, He K. Can Magnesium Enhance Exercise Performance?. Nutrients. 2017;9(9):946. Published 2017 Aug 28. doi:10.3390/nu9090946
16. Córdova A, Mielgo-Ayuso J, Roche E, Caballero-García A, Fernandez-Lázaro D. Impact of Magnesium Supplementation in Muscle Damage of Professional Cyclists Competing in a Stage Race. Nutrients. 2019;11(8):1927. Published 2019 Aug 16. doi:10.3390/nu11081927
17. Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17(12):1161-1169.
18. Castiglioni S, Cazzaniga A, Albisetti W, Maier JA. Magnesium and osteoporosis: current state of knowledge and future research directions. Nutrients. 2013;5(8):3022-3033. Published 2013 Jul 31. doi:10.3390/nu5083022
19. Orchard TS, Larson JC, Alghothani N, et al. Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study. Am J Clin Nutr. 2014;99(4):926-933. doi:10.3945/ajcn.113.067488
20. Zhang X, Li Y, Del Gobbo LC, et al. Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Hypertension. 2016;68(2):324-333. doi:10.1161/HYPERTENSIONAHA.116.07664
21. Tam M, Gómez S, González-Gross M, Marcos A. Possible roles of magnesium on the immune system. Eur J Clin Nutr. 2003;57(10):1193-1197. doi:10.1038/sj.ejcn.1601689
22. Moslehi N, Vafa M, Rahimi-Foroushani A, Golestan B. Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women. J Res Med Sci. 2012;17(7):607-614.
23. Kim DJ, Xun P, Liu K, et al. Magnesium intake in relation to systemic inflammation, resistance, and the incidence of diabetes. Diabetes Care. 2010;33(12):2604-2610. doi:10.2337/dc10-0994
24. Nielsen FH. Magnesium deficiency and increased inflammation: current perspectives. J Inflamm Res. 2018;11:25-34. Published 2018 Jan 18. doi:10.2147/JIR.S136742
25. Uwitonze AM, Razzaque MS. Role of Magnesium in Vitamin D Activation and Function. J Am Osteopath Assoc. 2018;118(3):181-189. doi:10.7556/jaoa.2018.037
26. Sartori SB, Whittle N, Hetzenauer A, Singewald N. Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment. Neuropharmacology. 2012;62(1):304-312. doi:10.1016/j.neuropharm.2011.07.027
27. Jacka FN, Overland S, Stewart R, Tell GS, Bjelland I, Mykletun A. Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study. Aust N Z J Psychiatry. 2009;43(1):45-52. doi:10.1080/00048670802534408
28. Grases G, Pérez-Castelló JA, Sanchis P, et al. Anxiety and stress among science students. Study of calcium and magnesium alterations. Magnes Res. 2006;19(2):102-106.
29. Takase B, Akima T, Uehata A, Ohsuzu F, Kurita A. Effect of chronic stress and sleep deprivation on both flow-mediated dilation in the brachial artery and the intracellular magnesium level in humans. Clin Cardiol. 2004;27(4):223-227. doi:10.1002/clc.4960270411
30. Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
31. Caillard, V. (1992). Sanofi Internal report MAB6-32. Paris, France. Unpublished work.
32. Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
33. Pouteau E, Kabir-Ahmadi M, Noah L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454. Published 2018 Dec 18. doi:10.1371/journal.pone.0208454
34. Bøhmer T, Røseth A, Holm H, Weberg-Teigen S, Wahl L. Bioavailability of oral magnesium supplementation in female students evaluated from elimination of magnesium in 24-hour urine. Magnes Trace Elem. 1990;9(5):272-278.
35. Firoz M, Graber M. Bioavailability of US commercial magnesium preparations. Magnes Res. 2001;14(4):257-262.
36. Uysal N, Kizildag S, Yuce Z, et al. Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best? Biol Trace Elem Res. 2019;187(1):128-136. doi:10.1007/s12011-018-1351-9
37. Reddy P, Edwards LR. Magnesium Supplementation in Vitamin D Deficiency. Am J Ther. 2019;26(1):e124-e132. doi:10.1097/MJT.0000000000000538
38. Magnesium Fact Sheet for Health Professionals. Ods.od.nih.gov. Accessed February 23, 2021.

MAGNESIUM CHELATE

This form of magnesium is especially important for muscle building, & recovery.

MAGNESIUM CITRATE

One study found that this form helped arterial stiffness in healthy overweight individuals.

MAGNESIUM BISGLYCINATE

Often used to treat symptoms of excess stomach acid, such as stomach upset, heartburn, and acid indigestion.

MAGNESIUM MALATE

Some believe this to be the most bioavailable form of magnesium. It’s found naturally in fruits, giving them a “tart taste.” Magnesium Malate can help with migraines, chronic pain, and depression.

MAGNESIUM SUCROSOMIAL

This form of magnesium helps you to effectively produce energy. It also supports the immune system and is critical for bone health and skeletal development.

MAGNESIUM TAURATE

This is the form of magnesium best for your heart. 

MAGNESIUM OROTATE

While also helpful for the heart, magnesium orotate is believed to be the best form for metabolic improvements. This makes it a favourite for athletes seeking enhanced recovery, energy and performance.

Magnesium Breakthrough has been detected free of Mercury, Lead, Arsenic and Fluoride. Each batch is produced under strict quality control standards. Gluten Free. 

Other Ingredients:

Cellulose (capsule), Nu-Mag®, Nu-Flow®, Silica.

Store in a cool/dry location away from direct light.

CAUTION

Keep out of reach of children. As with any product, discontinue immediately if adverse effects occur. Please consult a physician before beginning any new supplement, diet, training program, or if you are undergoing treatment of a medical condition.