Product Information:
Magnesium Breakthrough Benefits
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Promotes Heart Health
Magnesium is extremely important for heart health and blood vessel health.[18] Correcting deficiency appears to improve heart health and reduce the risk of death, although it is unclear whether supplementation alone is sufficient to treat these conditions.
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Improves the Ability to Deal With Stress and Helps to Relax
A magnesium supplement significantly reduces stress perception in people who are deficient in magnesium. Also, combined with vitamin B6 it was 40% more helpful than alone in very stressful situations. Findings support the need for magnesium supplementation for people living in conditions of chronic stress.[21][20][19]
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Helps With Mood, Cognitive Function, and Mental Health
A clinical trial showed that a magnesium supplement significantly improved mood after 2 weeks.[22][23] Another trial found that magnesium supplements improved mood in seniors.[24]
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Promotes Healthy Blood Sugar Control Already within Normal Range And Promotes Healthy Metabolism
You need magnesium to provide healthy levels of insulin. Then, insulin needs magnesium to deliver signals to your cells. Once sugar is inside your cells, you need magnesium to effectively burn the sugar for energy.
Magnesium is important for hormones that regulate blood sugar to function well.[25] Therefore, a magnesium deficiency can contribute to suboptimal blood sugar control.[26] Even when the blood sugar is normal, a supplement would still be necessary to achieve optimal levels.[27]
Magnesium participates in many biochemical reactions involved in breaking down stored fat and food for energy. So, a lack of magnesium can make your metabolism less efficient and you may find it harder to lose weight.
A large-scale systematic and dose-response analysis found that magnesium supplementation seemed to help with weight loss, especially in the midsection. Women and those with suboptimal blood sugar control seemed to reap more weight loss benefits from magnesium.[28] Participants seemed to weigh less and had smaller waist circumference if they took magnesium supplements.
The drop in waistline was small (less than an inch for an obese person) but statistically significant in this study, suggesting that it could be even more powerful when combined with deliberate caloric deficit and exercise.
Magnesium on its own doesn’t solve blood sugar problems or cause weight loss, but it can be highly beneficial in combination with diet and exercise.
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Supports Exercise Performance and Recovery
Magnesium supplementation improves speed and strength, possibly by making glucose metabolism more efficient.[29] It also supports healthy stress response to exercise, counteracts excessive muscle damage, and improves exercise recovery (400 mg/day, taken at breakfast).[30]
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Improves Sleep Quality
In a small clinical trial involving 46 elderly subjects with sleep struggles, 500 mg of daily magnesium supplement improved sleep quality, sleep latency, and cortisol.[31] Subjects also had more serum melatonin, slept deeper, and were less likely to wake up in the middle of the night.
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Builds Stronger Bones
Magnesium is the key building block of your bones.[32] Magnesium deficiency can weaken your bones by:
- Inhibiting healthy bone formation, creating brittle bones
- Increasing cortisol, which can contribute to lifestyle-related gradual bone loss
- Reducing parathyroid hormone
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Promotes Healthy Blood Pressure
A meta-analysis of 34 randomized control trials found that magnesium reduced blood pressure.[33] However, the effect size is clinically small (<2 mmHg). Therefore, it may be good for supporting overall health and healthy blood pressure, but you may also need other interventions to achieve healthy blood pressure levels.
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Promotes Balanced and Healthy Immune System
Magnesium is a crucial mineral for your immune system and activates Vitamin D, another key nutrient for healthy immune functions and balance.[34]
Overall, magnesium deficiencies tend to exacerbate or increase the risk of conditions that involve chronic inflammation.[35]
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Supports Vitamin D Activation and Metabolism
Both Vitamin D and magnesium have important roles in bone health, immune function, and metabolism. Magnesium is a cofactor in Vitamin D conversion and activation.[36] Some people cannot increase their blood 25-hydroxy Vitamin D levels despite supplementing with Vitamin D3 because they are deficient in magnesium. In other words, magnesium deficiency can make Vitamin D less effective.
Also, in people deficient in magnesium, high doses of Vitamin D3 could worsen magnesium deficiency and increase the potential for side effects of excessive Vitamin D3, such as having excess calcium.
Learn more in YouTube HERE
Not all magnesium supplements are created equal due to the differences in bioavailability.
Bioavailability correlates with health benefits. If the magnesium doesn’t reach your target tissue, you won’t reap the benefits from it.
Magnesium Breakthrough® provides the most bioavailable combination of different forms of magnesium on the market.
FAQ's
Can you take magnesium when pregnant?
Please note that Magnesium Breakthrough is not formulated or tested for pregnant women. Katemfe is not tested in pregnant women. It’s best to consult your OB/GYN before introducing any supplements during pregnancy.
For pregnant women, the National Institute of Health recommends a daily magnesium intake of 360 - 400 mg (slightly above the recommended amount for non-pregnant women over the age of 25)[37]. This is in part because hormonal changes during pregnancy cause more magnesium to be excreted through the urine.
What is the B6 in Magnesium Breakthrough made from?
Vitamin B6 improves magnesium absorption and bioavailability. A clinical study compared the effects of magnesium with magnesium combined with B6. They found that subjects who were going through a lot of stress experienced a 24% greater reduction in stress scores with magnesium and Vitamin B6 compared with magnesium alone. The Vitamin B6 in this product is made from carbohydrate fermentation (not potato starch).
Is this product safe for children?
Consult with your pediatrician. The recommended daily allowance of magnesium for children 9-12 is 240 mg/day which is lower than a scoop of this Magnesium Breakthrough®. If your pediatrician approves, you may want to start with half or ⅔ of a scoop.
What are the benefits of taking Magnesium Breakthrough?
- 8 types of magnesium make it the most complete blend available
- Promotes a healthy stress response
- Improves sleep quality
- Supports brain function, memory, and cognitive function
- Helps muscle building and recovery
- Boosts exercise performance for athletes, the elderly, and people with suboptimal health
- Improves mood and mental health
- Improves blood sugar control in people with normal blood levels
- May relieve some PMS symptoms and promote hormonal well-being in women
Scientific Studies
- “Chelated Magnesium Uses, Side Effects & Warnings.” Drugs.com, www.drugs.com/mtm/chelated-magnesium.html.
- Schutten, Joëlle C., et al. “Effects of Magnesium Citrate, Magnesium Oxide and Magnesium Sulfate Supplementation on Arterial Stiffness in Healthy Overweight Individuals: A Study Protocol for a Randomized Controlled Trial.” Trials, vol. 20, no. 1, 28 May 2019, https://doi.org/10.1186/s13063-019-3414-4.
- “Magnesium Glycinate Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD.” Www.webmd.com, www.webmd.com/drugs/2/drug-152090/magnesium-glycinate-oral/details.
- Uysal N, Kizildag S, Yuce Z, Guvendi G, Kandis S, Koc B, Karakilic A, Camsari UM, Ates M.Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best? Biol Trace Elem Res. 2019 Jan;187(1):128-136. doi: 10.1007/s12011-018-1351-9. Epub 2018 Apr 21. PMID: 29679349.
- Maypro. “Sucrosomial® Magnesium.” Maypro, www.maypro.com/products/sucrosomial-magnesium-a-source-of-magnesium-oxide-with-superior-bioavailability.
- McCarty MF. Complementary vascular-protective actions of magnesium and taurine: a rationale for magnesium taurate. Med Hypotheses. 1996 Feb;46(2):89-100. doi: 10.1016/s0306-9877(96)90007-9. PMID: 8692051.
- Rosenfeldt FL. Metabolic supplementation with orotic acid and magnesium orotate. Cardiovasc Drugs Ther. 1998 Sep;12 Suppl 2:147-52. doi: 10.1023/a:1007732131887. PMID: 9794088.
- de Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiol Rev. 2015;95(1):1-46. doi:10.1152/physrev.00012.2014
- Jacka FN, Overland S, Stewart R, Tell GS, Bjelland I, Mykletun A. Association between magnesium intake and in community-dwelling adults: the Hordaland Health Study. Aust N Z J Psychiatry. 2009;43(1):45-52. doi:10.1080/00048670802534408
- Grases G, Pérez-Castelló JA, Sanchis P, et al. Anxiety and stress among science students. Study of calcium and magnesium alterations. Magnes Res. 2006;19(2):102-106.
- Takase B, Akima T, Uehata A, Ohsuzu F, Kurita A. Effect of chronic stress and sleep deprivation on both flow-mediated dilation in the brachial artery and the intracellular magnesium level in humans. Clin Cardiol. 2004;27(4):223-227. doi:10.1002/clc.4960270411
- Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
- Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
- Pouteau E, Kabir-Ahmadi M, Noah L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454. Published 2018 Dec 18. doi:10.1371/journal.pone.0208454
- Bøhmer T, Røseth A, Holm H, Weberg-Teigen S, Wahl L. Bioavailability of oral magnesium supplementation in female students evaluated from elimination of magnesium in 24-hour urine. Magnes Trace Elem. 1990;9(5):272-278.
- Firoz M, Graber M. Bioavailability of US commercial magnesium preparations. Magnes Res. 2001;14(4):257-262.
- Uysal N, Kizildag S, Yuce Z, et al. Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best? Biol Trace Elem Res. 2019;187(1):128-136. doi:10.1007/s12011-018-1351-9
- DiNicolantonio JJ, Liu J, O'Keefe JH. Magnesium for the prevention and treatment of cardiovascular disease. Open Heart. 2018;5(2):e000775. Published 2018 Jul 1. doi:10.1136/openhrt-2018-000775
- Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
- Pouteau E, Kabir-Ahmadi M, Noah L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454. Published 2018 Dec 18. doi:10.1371/journal.pone.0208454
- Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362-370. doi:10.1016/j.mehy.2006.01.047
- Tarleton EK, Littenberg B, MacLean CD, Kennedy AG, Daley C. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial. PLoS One. 2017;12(6):e0180067. Published 2017 Jun 27. doi:10.1371/journal.pone.0180067
- Botturi A, Ciappolino V, Delvecchio G, Boscutti A, Viscardi B, Brambilla P. The Role and the Effect of Magnesium in Mental Disorders: A Systematic Review. Nutrients. 2020;12(6):1661. Published 2020 Jun 3. doi:10.3390/nu12061661
- Barragán-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F. Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial. Magnes Res. 2008;21(4):218-223.
- Guerrero-Romero F, Tamez-Perez HE, González-González G, et al. Oral magnesium supplementation improves sensitivity in non-diabetic subjects with resistance. A double-blind placebo-controlled randomized trial. Diabetes Metab. 2004;30(3):253-258. doi:10.1016/s1262-3636(07)70116-7
- Takaya J, Higashino H, Kobayashi Y. Intracellular magnesium and resistance. Magnes Res. 2004;17(2):126-136.
- Schnack C, Bauer I, Pregant P, Hopmeier P, Schernthaner G. Hypomagnesaemia in type 2 diabetes mellitus is not corrected by improvement of long-term metabolic control. Diabetologia. 1992;35(1):77-79. doi:10.1007/BF00400855
- Askari M, Mozaffari H, Jafari A, Ghanbari M, Darooghegi Mofrad M. The effects of magnesium supplementation on obesity measures in adults: a systematic review and dose-response meta-analysis of randomized controlled trials [published online ahead of print, 2020 Jul 11]. Crit Rev Food Sci Nutr. 2020;1-17. doi:10.1080/10408398.2020.1790498
- Zhang Y, Xun P, Wang R, Mao L, He K. Can Magnesium Enhance Exercise Performance?. Nutrients. 2017;9(9):946. Published 2017 Aug 28. doi:10.3390/nu9090946
- Córdova A, Mielgo-Ayuso J, Roche E, Caballero-García A, Fernandez-Lázaro D. Impact of Magnesium Supplementation in Muscle Damage of Professional Cyclists Competing in a Stage Race. Nutrients. 2019;11(8):1927. Published 2019 Aug 16. doi:10.3390/nu11081927
- Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17(12):1161-1169.
- Castiglioni S, Cazzaniga A, Albisetti W, Maier JA. Magnesium and osteoporosis: current state of knowledge and future research directions. Nutrients. 2013;5(8):3022-3033. Published 2013 Jul 31. doi:10.3390/nu5083022
- Zhang X, Li Y, Del Gobbo LC, et al. Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Hypertension. 2016;68(2):324-333. doi:10.1161/HYPERTENSIONAHA.116.07664
- Kim DJ, Xun P, Liu K, et al. Magnesium intake in relation to systemic inflammation, resistance, and the incidence of diabetes. Diabetes Care. 2010;33(12):2604-2610. doi:10.2337/dc10-0994
- Nielsen FH. Magnesium deficiency and increased inflammation: current perspectives. J Inflamm Res. 2018;11:25-34. Published 2018 Jan 18. doi:10.2147/JIR.S136742
- Uwitonze AM, Razzaque MS. Role of Magnesium in Vitamin D Activation and Function. J Am Osteopath Assoc. 2018;118(3):181-189. doi:10.7556/jaoa.2018.037
- Magnesium Fact Sheet for Health Professionals. Ods.od.nih.gov. Accessed February 23, 2021.
- Reddy P, Edwards LR. Magnesium Supplementation in Vitamin D Deficiency. Am J Ther. 2019;26(1):e124-e132. doi:10.1097/MJT.0000000000000538
- Magnesium Fact Sheet for Health Professionals. Ods.od.nih.gov. Accessed February 23, 2021.